COMPREHENSIVE MIXTURE GUIDE

Understanding interactions, synergies, and contraindications for optimal safety and experience management.

Alcohol

Severe Danger

Never combine GHB/GBL with alcohol. This combination causes unpredictable potentiation of CNS depression, significantly increasing the risk of unconsciousness, respiratory depression, and death.

Potential Effects:

  • •Severe respiratory depression
  • •Unpredictable unconsciousness
  • •Vomiting while unconscious (aspiration risk)
  • •Potential fatal outcome

Recommendation:

Absolutely avoid this combination under all circumstances. If alcohol has been consumed, wait at least 4-5 hours before considering GHB/GBL.

Benzodiazepines

Severe Danger

Combining GHB/GBL with benzodiazepines (Xanax, Valium, Klonopin, etc.) creates dangerous synergistic CNS depression, substantially increasing overdose risk.

Potential Effects:

  • •Profound sedation and unconsciousness
  • •Respiratory depression
  • •Amnesia and confusion
  • •Potential for coma

Recommendation:

Never combine these substances. If benzodiazepines have been used, wait at least 24 hours before using GHB/GBL due to the long half-life of many benzodiazepines.

Opioids

Severe Danger

The combination of GHB/GBL with any opioid (heroin, oxycodone, fentanyl, etc.) creates an extremely dangerous synergistic effect on respiratory depression.

Potential Effects:

  • •Severe respiratory depression
  • •Profound sedation
  • •Nausea and vomiting
  • •High risk of fatal overdose

Recommendation:

Never combine these substances under any circumstances. Wait at least 24 hours after opioid use before considering GHB/GBL.

Other Depressants

High Risk

Combining GHB/GBL with other CNS depressants like barbiturates, sleep medications (Ambien, Lunesta), or muscle relaxants creates dangerous additive effects.

Potential Effects:

  • •Enhanced sedation beyond intended level
  • •Respiratory depression
  • •Impaired coordination and judgment
  • •Potential unconsciousness

Recommendation:

Avoid combining with any other substance that causes CNS depression. Wait at least 24 hours after using other depressants before considering GHB/GBL.

Stimulant Comedowns

High Risk

Using GHB/GBL during stimulant (cocaine, amphetamines) comedowns can mask overdose symptoms and lead to dosing errors as the stimulant wears off.

Potential Effects:

  • •False sense of sobriety leading to redosing
  • •Sudden onset of GHB/GBL effects as stimulant wears off
  • •Cardiovascular stress from opposing effects
  • •Increased dehydration risk

Recommendation:

Avoid using GHB/GBL to manage stimulant comedowns. If stimulants have been used, wait until you are fully baseline before considering GHB/GBL.

Dissociatives

High Risk

Combining GHB/GBL with ketamine or other dissociatives can lead to severe disorientation, vomiting, and respiratory concerns.

Potential Effects:

  • •Profound disorientation and confusion
  • •Inability to maintain airway if unconscious
  • •Nausea and vomiting while dissociated
  • •Unpredictable behavioral effects

Recommendation:

Avoid this combination. If ketamine or other dissociatives have been used, wait until fully baseline (at least 3-4 hours) before considering GHB/GBL.

Critical Safety Information

The combinations listed above represent significant risks to health and safety. Even experienced users should exercise extreme caution and preferably avoid these combinations entirely.

Many GHB/GBL-related medical emergencies and fatalities involve combinations with other substances, particularly alcohol. The unpredictable potentiation effects can cause rapid unconsciousness and respiratory depression, even with doses that would be manageable when either substance is used alone.